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Hydroxypropyl cellulose(H-HPC)

Hydroxypropyl cellulose(H-HPC)

  • Categories:
  • Pharmaceutical Excipients
  • Comments:
  • 1.pharma grade
    2.non-ion type cellulose ether
    3.maily used as solid preparation collapse and bonding agent
  • Update Time:
  • 12-17-2018
Detail Information

Hydroxypropyl cellulose(H-HPC)

.Description

Hydroxylpropyl cellulose (HPC) is a nonionic water-soluble cellulose ether with a versatile combination of properties: it combines organic,solvent solubility, thermoplasticity, and surface activity with the thickening and stabilizing properties of other water-soluble cellulose polymers.

.Outstanding Characteristics

HPC is soluble in many polar organic solvents and in water below 38℃,but is insoluble in water above 45℃.HPC is highly surface-active, with low surface and interfacial tensions of solutions. It has a wide range of viscosities of varying concentrateions in water.

.Application

HPC is versatile: it is used in wide variety of applications, including food,cosmetics, pharmaceuticals, coatings, adhesives extrusions and molding paper,paint removers,encapsulateions inks, and many other applications requiring a film-former, stabilizer, suspending agent, film barrier, thermoplastic, or protective colloid.

.Grades and Types

Hydroxylpropyl cellulose (HPC) is produced in standard and premium grades. The standard grades is for Industrial uses, the premium grades, designated for manufacturing use only, are for foods, pharmacyeutical, and cosmetic. All viscosity types are available in each grade. Solution viscosities of the various types are shown in Table Ⅰ. Typical properties of the polymer and its solutionsare given in Table Ⅱ.

HPC  TECHNICAL  SPECIFICATIONS

Table l   viscosity of various solution types, mpa.s

Concentration in water, weight%

Viscosity Type     1         2        5          10

E          1500

            3000

F                    4000

                     6500

G                   150-400

H                            150-400

I                             75-150

J                                      150-700

K                                      150-300

Viscosities determined 25℃ using a Brook field viscometer with spindle and speed combinations depending on viscosity level. Ranges shown in this table are not necessarily current specifications.

Ⅴ.Table   Typical  properties

Appearance                      off-white, Tasteless powder

Particle size % min

  Through 30 mesh..........................................85

  Through 20 mesh..........................................99

Ash content (calculated as Na2SO4)  %,max...................................................0.5

Moisture content (as packed),%,max........................5.0

Solubility In water ....................clear, smooth solutions below 38℃

Solutions in water Viscosity...........................................See table l

PH...................................................5.0-8.5

Surface tension 0.1 % concentration Dynes/cm...........................................43.6

Interfacial tension,0.1 % HPC in water As refined mineral oil, dynes/cm.................12.5

Ⅵ.  Packing , Storage and Transportation

Package:  Plastics-paper bag outside, lined with PVC bag.

Storage :  seal tightly , Exposing to the sun and rain is forbidden, to avoid absorption of moisture and contact with acid and alkali

Transportation :  AS common moisture-proof chemical .

Hydroxypropyl cellulose(H-HPC)
  • Hydroxypropyl cellulose(H-HPC)
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